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custard cream (Cocimix pot de Luxe)

Yesterday

debuts new programmable pot Cocimix de Luxe and the first thing I did was this custard cream, had guests for dinner and wanted something sweet, according to them was very rich I would not probe me I'm on a diet rich custard also clear ;

Here I leave a picture of my two programmable pots and GM D Cocimix de Luxe, which worked yesterday the two hand in hand did 4 different dishes for my guests

Well I am not curl, here the recipe for flan with cream

Ingredients:

6 eggs 200 g sugar 500g cream
35%

200 grams of milk candy to the mold.

Preparation:

Place all ingredients in the Mycook jara less liquid candy, 2 minutes, speed 5, pudding mold candy and threw up the resulting mixture, cover the mold in the tray from the Luxe Cocimix put 4 cups of water meters, we roast and grill over pan, cover the pot with valve closed, menu, chicken 15 minutes, pressure II, let alone depressurized, remove the mold and let cool, when cold unmold and put in the fridge, minimum 2 hours before eating

PS as pudding mold was very crowded overflowed a little, but still and all went well and rich

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ASI NO!

Moody's heads out of the crisis they caused with record salaries
agency executives paid a bonus for helping to "restore confidence "while the U.S. Congress as an example of bad practice.

rating agencies have played out the financial crisis. Its credibility is at stake, the United States Congress has proclaimed them guilty of the crisis and its profits have fallen to the level of several years ago. Its executives, however, have turned the page to record salaries and bonuses, at least in the case of Moody's. The recent joint announcement by the company states that the remuneration of its chief executive, Raymond McDaniel, was up 69% in 2010 to the 9.15 billion dollars (about 6.4 billion euros).

The five highest paid executives of the firm distributed 20 million dollars, an increase of 60%. Moody's places great emphasis on variable pay, and justified by the increase in benefits by 2010, but like many companies, variable pay varies more upward than downward. The dome of Moody's won twice in 2005 although since then the operating income fell 17% and net profit about 10%. The firm made a cut in salary when the results are collapsed, but the upturn has placed them at record levels. Managers now earn more than in 2006, in full bubble, although then the operating profit was 63% higher. The crisis has left them profitable.

Among the items of compensation in 2010, a attention. Moody's awarded to its chairman, among other reasons, for their achievements in "helping to restore confidence in the ratings of Moody's Investors Service to raise awareness about the role and function of the ratings (...)". The award was approved weeks after the U.S. Congress has brought to the rating agencies among the culprits of the financial crisis has highlighted just Moody's as a case study about the wrongdoing that caused the crisis.

McDaniel was one of the executives who appeared before the congressional committee of inquiry into the causes of the crisis and the final report does not leave a very good place him or other executives Moody's acting under his orders.

"We conclude that the failure of credit rating agencies were essential cogs in the machinery of financial destruction. The three agencies were key tools of financial chaos. The mortgage-related securities at the heart of the crisis would not have been marketed and sold without their stamp of approval. The investors relied on them, often blindly. (...) This crisis could not have happened without the agencies. His skills helped the market to soar and their sales in 2007 and 2008 wreaked havoc " the report concludes.

The document notes that from 2000 to 2007 Moody's considered the highest credit rating (triple A) to 45,000 mortgage-related securities. The report looks outdated calculation models, the pressures on financial firms and how We placed the desire to gain market share at the quality of ratings. The commission said there was a "clear failure of corporate governance at Moody's, which failed to ensure the quality of tens of thousands of grades."

CEO of Moody's came to testify before the committee accompanied by Warren Buffet, the main shareholder of the agency. But Buffett was washed hands. "When asked if he was satisfied with the internal controls of Moody's, Buffett said he knew nothing about management agency: 'I had no idea, I've never been to Moody's, do not know where they are. " Buffet said he invested in the company because the business of rating agencies was "a natural duopoly, giving him an incredible power over prices," says the report of the committee.

Other testimony showed that meet the standards no priority was to Moody's. A former director of compliance, Scott McCleskey, told the commission how at a dinner then responsible for the area of \u200b\u200bskills, Brian Clarkson, dubbed the Dictator, boasted of the good results achieved by mortgage securities. The McCleskey approached and before All board members were snapped: "How much revenue has generated compliance this quarter? Nothing, nothing." When asked about it, Clarkson told the committee he did not recall that conversation.

Another former senior executive said how to get to Moody's in 1997, the biggest fear was to miss analysts in a grade. When he left, what everyone feared was that he considered that threatened the market share of the firm.

The commission revealed that a report sent to McDaniel emphasized that the three factors of competition between agencies, price, service and quality of ratings, the latter had become less important and even criminalized business, which "could put the entire financial system at risk," the report said.

Moody's went to take up to two months to discuss a structured financial product put 30 stamps each day triple. In 2006 he became a "factory of triple A". The results were disastrous: 83% of mortgage securities rated AAA that year ended up being degraded. Despite

"abysmal failure" which the commission relates, Moody's has maintained intact its cash bonus plan in 2004 and now his boss rewards for their efforts to restore credibility precisely has been damaged while he was in front company. The company has been awarded a bonus of 157% of its target. And the incentive of top executives has been "adjusted" another 10% higher by a survey on the satisfaction of investors.

The report also shows how the agencies were wrong again and again to assess the solvency of the institutions that had just dropping like Bear Stearns, Lehman or AIG. Moody's had to AIG a rating similar to that given to Santander or BBVA, and even after the bankruptcy of Lehman, when the Fed maneuvered desperately to save the insurer, the downgrade was only two steps, to A2, higher than that given to the vast majority English institutions.

In the transcript of McDaniel's statement, a sentence is highlighted: "Investors should not rely on the ratings [agency] to buy, sell or hold securities." It's advice the president of Moody's.

http://www.elpais.com/articulo/economia/jefes/Moody/s/salen/crisis/provocaron/sueldos/record/elpepueco/20110327elpepieco_1/Tes

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Cocimix de Luxe Pot Programmable offer clear

Well today is not an entry of food but a pot programmable to us help with cooking, especially for those who work at home, but for those that do not work outside the home but inside it is also great, is the new pot programmable Cocimix de Luxe, rich meals out, add the food in the pot, the programs and you forget about it until you finish cooking and you're home but keeps it warm until you arrive. The biscuits makes luxury and super-fluffy Altit, potato tortillas, meat, fish, etc ... and best of all you can cook without fats or oils on its menu board, so we are on a diet comes great, that certainly this year I will get my ideal weight after muuuuuuuuucho time and with the help of this pot is much easier because you can cook without fat.

Here you can buy

or send me an email to elchejulycar@hotmail.com

The new Luxe COCIMIX pot, to cook in 3 different pressures, choosing for each menu, cooking at low, medium or high pressure. As a preview, can vary the temperature from
70 º to 180 º C, so we got to our "touch" personal in the design and development of our recipes and dishes.

The display can look at the digital clock and when we schedule only necessary to set the time you eat. Supports programming period up to 24 hours for a meal ready when you want.

Intuitive and simple, the new screen or display is illuminated with different colors: yellow, pink, red, green to know, where is our pot Cocimix program. (Scheduled and expected to start cooking, cooking or over)
.
The color change is automatic.

As with all GM models, incorporating different Cocimix Menus Each menu has a preset time and which may vary to suit your tastes (more / less preparation time), as well as choosing the pressure (high, medium or low) and temperature. The program plate, oven and slow, the pressure is not eligible because they do not use, but if the temperature (from 70 º C to 180 º C).
menu incorporates a slow cooker to prepare traditional-style dishes without having to worry about the evaporation of liquids. New

internal memory in case of power outage, continue where you left off and finished cooking when the supply is resumed. A key feature of all models GM is redundancy in security systems, incorporating up to 12 steps to
you enjoy cooking with the added security.

Gift:: A 2 º Bucket Anti-stick Daikin or Steel + Basket + Cover + forceps to remove the tray (reference OP-017)
The pack sale for Cocimix de Luxe is:

- Daikin non-stick tray
-
barbecue grill - Accessories: measuring cup, spoon and recipe book to color.

We add:

- 2 ª A bucket stainless steel. Daikin or anti-adherent (to choose)

Ó
Well



- A safety glass top anti-fog cooking oven or iron as well as cooking sauces, keep the tray closed when with 2nd kitchen bowl a bowl.


- A silicone basket for cooking your vegetables steamed and avoid scratching the bowl.


- A Clip out the tray (reference OP-017)



And your warranty card with your bill



for 195 € VAT and shipping within 24 hours included
Apply COD no added cost.
Accessories: measuring cup, spoon and recipe book to color. Warranty
official invoice numbered
Pack Exclusive
FOR YOUR KITCHEN
+ Anti-stick tray Daikin + Basket + Cover + Clip remove the vial (Reference OP-017) .

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mortgages in yen: relief in the yen intervention by the G7


multicurrency mortgages back in the news by the decision this morning G7 to intervene in the currency market for the first time in more than a decade to curb the yen's rise after the earthquake makes a week. Yen, who yesterday scored 106.44 per euro, currently trades around of the 115 units which is a momentary relief for mortgages in yen

between dawn yesterday and today, the euro has appreciated 8% against the yen since the maximum (115.24) and minimum ( 106.44). using a converter euro yen, this virtual debt relief is a yen-mortgaged by 8% (16,000 euros in 24 hours for a mortgage of 200,000 euros) and a reduction in the monthly fee equal percentage from one extreme to another

movement today but also planting hope in the mortgage in yen, that despite the surge in shares this morning are still paying 50% above the peak of a few years ago, when the euro / yen trading above the 165 units. However, given the precedents of previous intervention g7, all mortgaged yen will now more aware of developments in the euro yen in the hope of a soil

weekly chart of the euro yen.

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unsweetened custard

The recipe is from the blog The cuisine of the Pacas

Ingredients:

5 egg whites (I of the boat's mercadona)

skimmed milk 600g 15g powdered sweetener (brand day)
1 teaspoon small vanilla flavor

Preparation:

Place all ingredients in jar Mycook and schedule 10 minutes, 90 º, Speed \u200b\u200b4, remove and put into clay pots , and the refrigerator cool, then sprinkle cinnamon over

PS as I am to diet I put cookies out 6 units
me

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The Final Solution (2001)




Title Original Data - Conspiracy
Year - 2001
Director - Frank Pierson Cast
- Kenneth Branagh, Stanley Tucci, Colin Firth, Barnaby Kay, Ben Daniels, David Threlfall

Synopsis One
20 January 1942 a meeting took place in a mansion in a village southeast of Berlin that would make the history of the Jewish people of Europe and therefore the world changed radically. That meeting called by perhaps the most sinister, but also one of the most exciting time Nazi, Reinhard Heydrich, and organized by the SS Colonel Adolf Eichmann is told in a brilliant in this film produced for television in 2001 and directed by Frank Pierson.


"final solution", a title much more successful in the original English "Conspiracy" (clearly designed to attract Anglo-Saxon history means knowing as much as I bicycle brake) speaks of as the systematic killing and forged organized the Holocaust. But it does so without sensationalism, if falling into cheap sentimentality abounds. Nor

seek to present the Nazis as evil beings with tails and horns. In contrast, smoke, drink, eat, laugh, get angry, listen to music, as we do. The difference is that they do while they talk quite naturally of how they will eliminate millions of people.

The film is supported by a fairly good script, without artifice, but not a mass film. No shots or explosions and people screaming, but people thinking and talking, it is therefore not a film or mass media phenomenon. With great historical accuracy and verisimilitude in recreating the parties do not know.

-screenwriter Frank Pierson likes of Alan J. Pakula, Sidney Lumet and Norman Jewison, the director is to blame for that work, it is limited to telling the story, take advantage of the great actors and put the camera where they send the fees. Others would give young directors to seek rare planes. Big mistake. Wonderful photography

Stephen Goldblatt ("Cotton Club") that takes advantage of simple lenses while others need filters to get interesting.

But as it was logical that we find the power of a movie theater is inevitably cut players, with Stanley Tucci and Kenneth Branagh and a secondary mighty convincing and conflicting with the authority in some cases even a little more defined and cartoony.

Certainly there is a German film "The Wannsee Conference" of 1984 also speaks of the topic, although this is much better without doubt. Gourmet palates and only interested in the subject. (Vircenguetorix: BFI)

Download:
http://www.mediafire.com/?mp9qxtffajgbt4u

Subtitles (English)
http://www.mediafire.com/?j6p25m0o1wz7vf6

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GOODS: QUESTION OF SIDING

Not one in twenty tons of cargo that moves in Spain does by rail, a figure that says very little about the consistency of our transport system. If no one disputed that the truck is unbeatable for the parcel, consumables and general merchandise retail, not much point in keeping them loaded road thousands of steel, coal, cement, chemicals, fuels, containers and other goods and in the surrounding countries should take their natural environment in the railway.
There are several historical reasons for this situation. We have a network and very poorly distributed radializada, whose design is essentially the same as existed in the nineteenth century and also the line density is insufficient for the size of the country, all due, and therefore a late industrialization and very localized. In addition, taking advantage of a situation of near monopoly, the railway companies before the Civil War did little to prepare for a competitive environment. The long post-war conflict and extended nearly three decades poor state of our roads. The development, based on shortsighted measures, opted for the use of the road as an alternative economic and social development.
With democracy, railway investments were focused almost exclusively on high speed, ignoring the conventional network, which they have to use the freight cars. The railway companies themselves have not managed to meet demand quickly to increasingly demanding industry, especially in material availability and reliability of journey times. For this reason, most companies have been forced literally in the last forty years without rail.
One cause has also been very present in this drift: the chronic shortage of private sidings. These pathways are located in the factories, mines, industrial sites and ports for loading and unloading of cars directly, avoiding intermediate handling. Its shortage is acute in recent decades by the suicidal blindness of many responsible for the railways, rather than encourage the maintenance and creation, did the opposite, more expensive and difficult to open new branches and even contributing to the closure of many .
An example of this misguided policy was in the 70's, attempting to create power stations as an alternative freight sidings to factories. Through a so-called intermodal, short-haul trucks would load the goods industries, to be transferred to central stations where wagons trasvasarían to take them to other central stations, where the new road would bring both to their destinations. The logical consequence of this system was that the trucks were made quickly with full transport from origin to destination, making the central station in little more than a site for urban use.
only large companies were able to maintain their own sidings have continued to use rail transport. Review the list of Asturias companies that move goods by rail (Aceralia, Tudela Veguín, Repsol Butano, power plants, CLAS, etc.) is review a list of sidings. Their existence has been allowing the Spaniard rail to be one that moves more goods around the country, because much of the rest of Spain and lay-bys are just a memory.
A policy to improve transport of goods by rail must start with direct access to industrial facilities, recovering old sidings and promoting the creation of new ones. Is simple and cheap.

Japanese

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The Nikkei recorded the third largest fall in its history and its biggest drop since October 2008 lasted

bags have suffered a new setback today fear of their nuclear status. The Nikkei and Topix have been the third largest fall in its history and the biggest drop since the October 16, 2008. The Nikkei has tumbled 10.55% to 8605.15 points, while the Topix has cut a 9.47% to 766.73 units.

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Emilio - Optimism and Illusion 2

Emilio lasted - Optimism and Illusion 2 from Ivan Torres Ramon on Vimeo .

Emilio

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Emilio lasted - Optimism and Illusion 1

Great conference lasted about Optimism and Illusion. "Emilio Pamies lasted a degree in Economics and Master of Business Administration School of Administration and Management (ESADE) and BA in Economics from the Autonomous University of Barcelona. He has been Assistant Professor of several universities, including University-Business Foundation at the University of Navarra, Pompeu Fabra University, Business School and INEDE Caixanova. Is an External Riofisa and ADOLFO DOMINGUEZ. It has also been a director of consumer goods companies such as Martini Rossi and Yoplait-ATO. At present and for more than 20 years, our instructor works as a consultant and trainer in national and multinational companies from various sectors such as: MICROSOFT, TELEFONICA, ONO, Inditex, AON GIL & CARVAJAL, ALCATEL, BARCLAYS, BRISTOL-MYERS SQUIBB, WILLIS, CAJA MURCIA, SANITAS, BASF, BSCH, BBVA, IKEA, Riofisa, MANGO, MICROSOFT, RENFE, VILLEROY & BOSCH, UDV, PHILATELIC FORUM, UNILEVER, ZURICH, WINTERTHUR, HEWLETT PACKARD, ...

Emilio lasted - Optimism and Illusion from Ivan Torres Ramon on Vimeo .

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Constantine (DVDRip)



Review:

John Constantine (Keanu Reeves) has been to hell and back. Born with a gift he did not want, the ability to clearly recognize the hybrid angels and demons that walk the earth in human skin, Constantine was driven to take his own life escape the tormenting clarity of his vision. But failed. Resuscitated against his will, he found himself back in the world of the living. Now, marked as an attempted suicide with a temporary life expectancy, he patrols the earthly border between heaven and hell, hoping in vain to earn his way to salvation by sending the devil's foot soldiers back to the depths.

But Constantine is no saint. Disillusioned by the world around him and at odds with the past, is a bitter hero who drinks too much, takes a hard life and scorns the very idea of \u200b\u200bheroism. Constantine will fight to save your soul but do not want your admiration or your thanks, and of course not your sympathy. All he wants is a reprieve.

When a desperate but skeptical police detective Angela Dod-are (Rachel Weisz) enlists his help in solving the mysterious death of her beloved twin sister (also played by Weisz), their investigation takes them through the world of demons and angels that exists just beneath the landscape of contemporary Los Angeles. Caught in a catastrophic series of otherworldly events, the two become inextricably involved and seek to find their own peace at any price.

Data:
Format: AVI
Language: English
Subtitles: English
Quality: DVD-RIP The best

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X RxCover-up and contamination Theories

X Rx

Intending to share the journey of treating XMRV. Nothing herein should be construed as medical advice.

In January 2011, I began to work for the WPI, but the content of this blog does not represent the institute. It is personal.
Any opinions expressed are mine alone.

Sunday, March 6, 2011

Cover-up and contamination theories

While the days, weeks and months pass, the scientific community continues to work on what isn't, instead of what is. The question of how a lab contaminant produces an immune response in patients hasn't been addressed by any of the contamination theorists. And how do you manage to contaminate the patients' samples at a higher rate than the controls when all samples were blinded and run at the same time? In fact, it is the patients that are contaminated with a family of MLV-related retroviruses, not Dr. Mikovits' lab.

This abstract was presented at CROI a few days ago:
XMRV Probably Originated through Recombination between 2 Endogenous Murine Retroviruses during in vivo Passage of a Human Prostate Cancer Xenograft. Paprotka
Many questions arise without the full paper, but it seems that far from showing XMRV to be a lab contaminant, the study shows what may in fact have happened. Human and mouse endogenous retroviruses recombined through subsequent passages in vivo (in mouse) to produce a fully replicative xenotropic exogenous retrovirus, that in fact may prove to be the most infectious human retrovirus yet. In animals, similar viruses are communicated casually. Lombardi et al demonstrated that this new human retrovirus is circulating in the blood of as many as 10 million Americans. A public relations nightmare. So what did the scientists who said this was impossible do? First they denied its existence, then tried to suggest results were the result of mouse parts in their reagents, but none of the arguments have in any way refuted the data of Lombardi et al or Lo et al, who rigorously ruled out contamination. What they have shown is that it is possible to produce XMRV in a lab. Like the murine retroviruses, recombination events produce new pathogenic variants. See my post from September 10 about Sandra Ruscetti's work: Lessons from the murine retroviruses

As for the 22Rv1 cell line being the source of XMRV contamination responsible for the whole mistaken affair, none of the labs involved in the Science paper Lombardi et al, have ever used this cell line. They couldn't have contaminated subjects' blood with virus produced by a cell line which all three investigators at different institutions can prove beyond a shadow of a doubt never entered their laboratories (personal communication). Sillier still, is the idea that this supposedly singular event was the source of infection, since it has only been around since 1999: A new human prostate carcinoma cell line, 22Rv1. Sramkoski

My guess is that passing lots of human tissue through mice and then culturing in the laboratory for now more than four decades produced the conditions to enable a very unlikely event- by giving it many chances to occur. A probable place for this to have happened was in the creation of live attenuated virus vaccines where virus is made less virulent with multiple passes through animal cells in tissue culture. The earliest live polio vaccine was made by Hilary Koprowski using Swiss albino mouse brain cells. The first dose was administered to a child in 1950. He also used monkey kidney cells which were implicated in passing SV40 to humans. Albert Sabin's live polio vaccine was produced from attenutated virus obtained from Koprowski.

Mouse cells and the cells of other species have also been used over the years in the creation of other vaccines. Some vaccines, including attenuated Measles and Mumps in the MMR, are grown on duck and chick embryo cells. Domestic fowl have endogenous retroviruses, avian leukosis viruses (ALVs or ASLVs), that do very similar things to the gammaretroviruses. Recombination events are involved in pathogenicity and they can infect the cells of other species in tissue culture. XMRV requires the XPR1 receptor to infect cells. The XPR1 receptor is ubiquitous in mammalian cells. Lab mice are resistant by virtue of XPR1 polymorphisms. The alpha retroviruses use a receptor called TVB. TVB is a tumor necrosis factor receptor that is most likely the avian homolog of a TRAIL (TNF-related apoptosis-inducing ligands) receptor. Here is a paper about the receptor: A Fifteen-Amino-Acid TVB Peptide Serves as a Minimal Soluble Receptor for Subgroup B Avian Leukosis and Sarcoma Viruses. Knauss . The abstract contains the following sentence: "This peptide was sufficient not only for binding to ASLV-B but also for activating viral entry into mammalian cells that lacked the cognate viral receptor."

Here are two recent papers which should be giving someone pause, but there is no evidence that anything is changing in the status quo at the CDC. Head in the sand or worse?

• Endogenous retroviruses as potential hazards for vaccines. Miyazawa
• Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets. Miyazawa

Beta retroviruses, e.g. mouse mammary tumor virus (MMTV), may also be present in tissue culture of murine cells. The first PubMed paper seems to have been published in 1948 when the "milk factor" was first identified on electron microscopy in tumor prone mice:
A particulate body associated with epithelial cells cultured from mammary carcinomas of mice of a milkfactor strain. Porter .
MMTV is a vertically transmitted endogenous retrovirus that causes cancer when it inserts near an oncogene. Vertical transmission of murine breast cancer by adoptive nursing was demonstrated in 1936 by Dr. John Joseph Bittner. It was formerly classified as a simple retrovirus, but transcribes a regulatory protein similar to HIV, so is the first complex murine retrovirus identified. MMTV codes for a superantigen that stimulates T lymphocytes which in turn stimulate B cell proliferation. At puberty the virus enters the mammary glands with migrating lymphocytes and infects proliferating epithelial cells. MMTV can be transferred exogenously or endogenously through the germ cell line; the later infection produces virus present in every cell of the body. Mice that acquire the infection this way have a higher incidence of tumors. In lymphocytes, it may cause a T cell leukemia. MMTV has an enhancer region in its U3 long terminal repeat that activates the virus in mammary cells. It is activated by estrogen and other glucocorticoids, including progesterone. It is especially responsive to the synthetic steroid Dexamethasone which is used to induce lactation in the dairy industry. And a few new MMTV papers.

• Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis. Ross
• Mouse mammary tumor like virus sequences in breast milk from healthy lactating women. Johal
• Mouse Mammary Tumor Virus in Anti-Mitochondrial Antibody Producing Mouse Models. Zhang
• Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer. Arendt

Gamma retroviruses are used as the backbone for gene vector therapy. It is known that retrovirus-mediated gene therapy of SCID-X1 can lead to leukemia and lymphoma because proto-oncogenes can be activated as a consequence of vector integration. Gammaretroviral vectors preferentially integrate near transcriptional start sites and CpG islands.

• Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. Hacein-Bey-Abina
• A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Scobie
• Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy. Davé

Another place for it to have happened or to be happening, as demonstrated by the Paprotka CROI presentation, is in the creation of human to mouse xenografts. It turns out that by transplanting human tumors into mice and passing the tissue through subsequent generations, it becomes possible to establish tumor cell lines that couldn't be established before. Also xenografts are used to study tumors, e.g. specific tumor immunogenicity and response to treatments. Why the presumption that the recombination that occurred in the Paprotka experiment was a unique event? They were fiddling with mouse viruses in the lab in the 1930s. The first outbreak of Epidemic Neuromyasthenia was in LA in 1934 and involved hospital staff. And suddenly the CDC is worried about lab workers and testing archived specimens. It would be funny if it weren't so incredibly sad.

Take a look at this fascinating paper that covers a lot of material including the problems with xenotransplantation:
The discovery of endogenous retroviruses. Weiss

Are we to believe this recombination event occurred only once and that a pathogenic MLV-related human retrovirus is only produced by one particular cell line? Told to us by some of the very scientists that said it was impossible? Anyone smell a cover-up? Much easier to destroy a seminal work than admit that there may in fact be a family of XMRVs. Careful reading of the Science paper shows that the monoclonal antibody used to detect XMRV envelope in Lombardi et al detects all known xenotropic, polytropic and ecotropic MLVs. Antibodies made by patients recognized specific envelope and gag proteins. PCRs were optimized for sensitivity, not specificity. And quite possibly there are many other recombinant animal retroviruses infecting humans as well, created in laboratories and injected into almost everybody in the industrialized world, because of arrogance.

Putting it all together, it seems quite plausible that batches of vaccines containing retroviruses that are infectious to humans have been going out for over half a century. Much of what I've written here has been known but ignored for a long time. The assumption was made that endogenous animal retroviruses couldn't harm people. It's becoming clear that this was a very incorrect assumption.

So is there motivation for the cover-up and baseless attacks against Dr. Mikovits? They cannot attack the data because it is impeccable. Coffin and Stoye wrote the commentary in Science. Have they retracted it? Coffin said at the CFSAC in October 2009 that "This is as good as it gets...". If this were HIV/AIDS, the year would be 1983. We have much still to learn about human MLV-related viruses. Is it even remotely possible that the findings reported in Lombardi et al were the result of contamination of their reagents? No more likely than that the retrovirus described by DeFrietas et al in 1991 was contamination. Had the CDC done something then, we could have prevented the autism epidemic and a second generation of infected people. Instead they buried DeFrietas' work by withdrawing all funding. Deja vu?

Posted by Jamie Deckoff-Jones MD at 1:37 PM

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The "Shock Doctrine" applied to the Catalan sanitat

DEMPEUS per la salut pública
En defensa del Sistema Nacional de Salut amb tot el seu caràcter assolit: públic, universal, de qualitat, integral, solidarity and of fairness guaranteed. 02/03/2011 GMT 1

The "shock doctrine" applied to the Catalan health

collective @ 11:28

Naomi Klein in Shock Doctrine , tells us many things. The latest statements by the Minister Ruiz made us think about this doctrine.

Of the seven measures announced by the Minister to reduce spending and comply with the goal of cutting 10% of budget The most aggressive is the elimination of programs to reduce waiting lists and announced that non-urgent patients may wait over 6 months (how long) to be operated. But is not the only measure to report, the end of the model involve many local grievances for rural Catalonia and it is not clear that means less spending and together with the extent of incentives for efficiency brings us to model only area that has implemented in the Madrid of the PP government with all the shortcomings that we have been reporting on this blog in recent months.
The new health care model promoted by the CiU is intended for public health to worsen significantly in the country, taking advantage of the economic crisis, the benefit of private healthcare. In this regard we recommend the article by Martinez Angels Gender, crisis, violence and health which compares the consequences and measures taken in the crisis of 29 with the current crisis.

Discuss Boi Ruiz's statements to the NOW: "Health give more money to hospitals more productive," also to Europa Press, "Los fading presupuestarios the Catalan Health will make its Listas Crecer 3% of non-urgent waiting, according Boi Ruiz, "El Pais" remove Health the right to be operated at a maximum of 180 days "and" La Vanguardia " CC.OO. Health reports that will eliminate the programs in order to reduce the waiting Listas .

And then the article NOW, we have chosen because it lists the seven measures proposed by the Minister Boi Ruiz.

THE NEW MODEL HEALTH

Minister of Health, Boi Ruiz announced yesterday unions and employers plan cuts in health, which goes through the end of the proximity model and encourage centers more productive.'s plan cuts slows 60% of investments

LARA BONILLA - BARCELONA - 01/03/2011

action plan to ensure sustainability of the health system with 850 million less than budget or which is the same, 10% less than last year. To do so, the Minister of Health, Ruiz Boi, was presented yesterday to the sector during the Council meeting Catalan Health, a seven-point plan which hopes to reduce between 20% and 25% administrative spending , 20% more spending on equipment and between 8% and 11% spending on health services and pharmacy.

Structure administrative
S'aprimarà the top 10% of senior managers
The first to fall were the managers of the Hospital. One person centralize management, which previously delivered three people. But this is only the beginning. The aim of the Department of Health is to reduce 10% of the health system managers and end the duplication of charges and excessive bureaucracy. All in all, estimated that the structure is reduced by 20%. With this simplification, the Department of Health expects to save between 20% and 25% of the budget in this area.
Catalog
benefits will not be accepted without drug benefits or funding
This is to negotiate with Madrid. The government wants to increase its power to influence decisions and will not accept any new provision in the health care available and no new drug that is accompanied by a budget. Reorder
services
The end of the proximity model: Not all hospitals will all
It can not be guaranteed that patients will have all services close to home. This was one of the obsessions of the previous coalition government, which gave many regional centers and clinics with new technologies to prevent displacements. Now is reorganized according to performance centers and critical mass. Just some extra services, such concerted activities to reduce waiting lists, and review the catalog of 14 surgical procedures to guarantee six months of waiting. Patients with urgent conditions should not expect more. Also be reduced by 2% rates of consultation with schools. Incentives for efficiency

Improved productivity costs and outcomes
is one of the most innovative measures. Health encourage and recognize the work of hospitals and health centers more productive, which reward you with a budget higher than other schools do not get as good results. These reward efficiency. New technologies

optimization of new technologies and research
Remove the recipe on paper and electronics as well as promote the use of new technologies throughout the health system to reduce costs. The use of email replaced, in some cases, the conventional consultation.
Investment Program
stopped 60% of the works and new services
Health reviewed not only investments but also screened la posada en marxa de nous equipaments i serveis. Només pot garantir un 40% de les noves inversions. La resta o s'aturaran temporalment o no es faran. El departament ho concretarà d'acord amb el territori i vol que siguin les entitats municipalistes les que decideixin les inversions prioritàries.
Més capacitat de decisió
Enfortir la confiança entre gestors i professionals
Es dotarà de capacitat els centres perquè puguin participar en els processos de decisió. Una mesura amb la qual esperen guanyar-se la confiança del sector i reforçar l'autonomia dels professionals. La majoria de mesures per contenir la despesa es volen pactar centre per centre.

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10 anys de l'ACAF

patients on chronic respiratory: asthma and COPD

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The Tafanera overwhelmed and grappling to investigate the cause of the worsening of my condition. Since June 2010 I know that anomalous values. Since December I have anemia, the cause is not known because neither has destabilized a medicated hypothyroidism. I am in the hands of medical specialists and four overall, a lot of tests and I need to move from town to the latest ... How serious is something that is being developed as we made salat. be that people no matter how superfluous? The VIPs who are not dying because we can and also without the bad taste to give the tin? Well they say and stop the hypocrisy and cynicism parked. Isabel Saez Altet # 1 Elizabeth, with the aggravating circumstance that until they tell you t'operen firm that does not begin to count the time waiting list. And you're right, public health, the public no longer VIPs, for them there is no waiting lists or any kind of cut. Elena Alvarez és més de fer a way-we consumidors of private, if tenim prou diners! A scandal! Angels Switzerland, Ciba, had to synthesize a new substance whose consequences they never imagined, thalidomide. After an extensive testing period, did not complete its development to find no significant pharmacological effects. However, another German company, Chemie Gruenenthal assumed responsibility for further development of this substance in 1954. According to the same German company, conducted experiments with thalidomide in monkeys, an essential step in the evaluation of the drug before being applied to humans, and there were no side effects. Again, rabbits, rats and dogs pregnant women they were given the medication for several weeks. Much later discovered that the animals received thalidomide at a wrong time and / or in such large doses that the fetuses had died. In short, the tests were done incorrectly and the results were falsified. Based on these alleged "evidence", the German authorities approved thalidomide for humans. They had no reason to reject it, because everything was reported normal. Also joined the fact that it was not until 1961 when it was introduced in Germany specific laws on drug control. Thus, the transition to market thalidomide was quite simple. Initially

marketed as a treatment for epileptic seizures, was later shown that this treatment was ineffective. Then used in a trial of a new antihistamine in the treatment of allergy. After a while, found that had no effect. However, in each of these tests that were conducted showed that itself was quite effective as a sedative. Finally, after many rounds, the final destination of the drug was to treat nausea, anxiety, insomnia and morning vomiting of pregnant women. Three years later, in 1957, thalidomide became the drug of choice to help pregnant women. Its use spread quickly the following year and was introduced in several countries in Europe, Africa, America and Australia.

The fury of the new drug was evident, advertising left no room for doubt "was completely safe for pregnant women" and the company's success was apparent Gruenenthal Chemie. However, a year before being marketed internationally (1956), the first child was born with the effects of thalidomide. Of course back then did not have any suspects. Although the malformations are rare, can occur without any specific cause. It was not until four and half years later that isolated event when an Australian obstetrician, William McBride, he realized that something was wrong. Detected within a very short time, almost identical malformations in three newborn babies. It was not normal, such anomalies are a few for each decade, but not in three babies at the same time. The frequency is out of the ordinary and there is clear evidence that there was more than a cause spontaneous.

1. What that obstetrician diagnosed in babies was focomielia. A rare congenital condition in which there is a lack of development of all or part of legs and arms. But also other abnormalities appeared less rare in other infants, deafness, blindness, internal malformations of organs ...
   
   
   
   After detecting these abnormalities McBride sent its comments to the Lancet, a prestigious medical journal. However, its publication was delayed a few months "for lack of space in the magazine. But he was not the only one who found that things were going very badly. Obstetricians in all countries where thalidomide was introduced as alterations observed as rare as the focomielia was appearing frequently. At first they did not know what he was, raised environmental explanations, infections, x-rays, toxic substances, etc. It was not until on November 11, 1961 when another physician, Dr. Lenz became clear that the culprit of all these malformations was thalidomide. 5 days after its discovery, when he felt he was completely safe for the research he had done, he telephoned the company Gruenenthal Chemie. It took days of intense discussions with company representatives, authorities and experts before the drug was withdrawn, mostly by how the press would react. Chemie Gruenenthal continued to deny the teratogenic (causing malformations) of thalidomide. But increasingly, the suspicion grew that not exactly denied by honest ignorance, but in order to weaken the charges against the company.
2. Meanwhile, throughout this period of time, more than 15,000 newborns worldwide suffered from the drug, of which fewer than 5,000 survive today. It did not take in the events referred to as "The Thalidomide catastrophe" and the name of the drug became the paradigm of the pharmaceutical act more despicable.
   
   After the event, many countries gradually began to enact laws to control drugs and the requirement that they be subjected to drug tests and tested in animals, as well as clinical trials before marketing people. also began the era of financial compensation to all affected families in all countries where the drug was distributed. He turned to look closely Chemie Gruenenthal evidence presented at the time the German authorities to be approved as a drug and that was when it was discovered all the irregularities they had committed. It took the company to court and forced to whom it was rewarded financially to the victims. The drug had been billed as "totally safe" became one of the most teratogenic drugs which have been known, sufficient intake of a single dose to produce serious birth defects and 40% of the victims died before their first year. Still, it is prescribing in some countries as a treatment for leprosy and some cancers.
3. About:
   The History of Thalidomide

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• Dive into Adventure: Make Catholic Medicine in Valencia!
• categories Pharmacology, Medical History
• , Obstetrics , Public Health, Toxicology
• Tags
• embryo, fetus , malformations, thalidomide
• " The Inner World of the Cell

From that small mistakes in medical websites will spread to the halls of medicine ...

1. "
29 Responses "The Catastrophe the Thalidomide "

Jokin

says August 24, 2006 at 5:39 PM Great review the issue of thalidomide, we all know but few know exactly where it came However, the last sentence is not quite right: Still, it is prescribing in some countries as a treatment for leprosy and some cancers.

I would not say "yet", which connotes little interest in the consequences or what the patient may suffer treatment ... After many years when production ceased, has recently begun to be used again in cases of leprosy and certain tumors (eg multiple myeloma) in which other treatments have been ineffective, and where the person (whether man or woman) is not of childbearing age or take measures to prevent offspring (by written contract and signed).

is not a drug of first, second or third choice, but it is another tool to consider.

When all else fails, what one would not cure a cancer?

Other drugs are also teratogenic (as extended isotretinoin) and even well used. The important thing is to realize that there is no medicine completely safe (all is a poison pill) and that has to assess the expected benefits against the risk acceptable ...

omalaled says August 24, 2006 at 5:38 PM Thank you for your comment on my blog.

Now, I have two suckers, but the truth is that the bombardment of questions to the gynecologist during pregnancy was fierce whenever prescribed something. Is it safe? How many years have you used? How many years have you prescribing?.
1. And although we said that prescription drugs were safe, never we trust 100%.

   Still, most exciting is the "nose" of the perpetrators, saying things they know are not true. Anyway ... these things are happening? Cheers

   Misslucifer

   
   says:

   August 24, 2006 at 9:25 PM
   

   Wow, I had no idea. It's terrible. I remember the movie Constant Gardener, uf ...
   
Anonymous says:
2. August 25, 2006 at 7:48 a.m. I have read that thalidomide is used in cats do not know if will have some other veterinary use. a link that shows different effects between humans and animals of various medications. is curious that a chicken can die from eating marzipan (almond is) and dogs, cats and horses will feel bad chocolate.

   RD

   says

   
   

   August 25, 2006 at 1:22 a.m.
3. Noooo ... Maybe that's why I never decided to be a pharmacist or doctor ... A lot of responsibility.
   Leonardo ... from Colombia

   says

   August 25, 2006 at 4:33 a.m.
   I remember that in an episode of House's use as a treatment ... was Damned? ...
4. In my country ... and suppose that many of lationamerica all lasted longer, it is known (and it sounds pedantic true) that this area tend to send the drugs banned in other countries ...
   pipistrellum

   says

   August 25, 2006 at 7:34 a.m. According
5. 've read there are two forms of thalidomide with an identical chemical composition. Good and bad. Glucose can rotate polarized light to the left (levosa) or right (dextrose), the usual. Has different optical anisotropy. Both have the same chemical composition, but have a different 3D shape. This may not have any effect, change the properties of a chemical or even make something happen from a medication to a poison, as the case of thalidomide. During the production of thalidomide produce a chiral half and half of another. Could be separated, but into the body some molecules will be converted in the form teratogenic. (Curiosity teratogenic = generating monsters, monstrous Terabyte = Byte) A curious but important fact is that the same molecule can smell like lemon or orange just by changing the chiral form, a mirror is another. All told this on the first link, if anyone wants more information. I recommend the article is very interesting

   link me what happened

   chemist in the jabber room.

   A preguntilla, not if you will. When I look at a food ingredient, dextrose and almost always indicates a very rare case Levosa?

   That has some reason? The process improves the body or is that normal glucose produced / manufactured is dextrose?
6. Marcos says

   August 25, 2006 at 8:39 a.m.

   Hello!

   First of all I would like to congratulate its Shora indispensable blog. Let me add something about the sugars pipistrelum said.

   I think you're a confusion of terms, let's see, glucose or dextrose (a synonym) is a natural simple sugar which is also a component of sucrose with fructose. The correct terms to speak of the stereoisomers are left-handed and right-handed forms, substances that have the property of rotating the plane of polarized light to the left or right.
   A greeting. Greetings
7. pipistrellum

   says

   August 25, 2006 at 9:56 a.m. levosa The truth that I have not found anything, but I think I heard somewhere. However, in English if displayed resulting in levose. From here

   "What I am getting at now Is That The Same Some Substances with chemical formula rotate polarized light to the right, plow dextro-rotary, as, for instance, What is Known as dextrose. Others rotate it to the left, plow levo-rotary, as the Substance Called levose. Both themes are of glucose. Substances Which There Are So Give the Same chemical reactions Which Can Only Be Distinguished by Their Being left or right rotary. "
   

   Treiral_

   
   says
8. August 25, 2006 at 1:59 PM
   Very good article, very interesting too ... Greetings!

   Shora

   
   
   
   says
   
August 25, 2006 at 2:00 PM
9. Omalaled: Indeed, as a pregnant woman have to take fewer drugs, better. Of course, vitamin supplements, iron and folic acid are essential. Although they are not drug as such, but an extra supply of something that is taken daily. Hopefully stuff does not happen again and that controls on drugs that were created to prevent it from happening. Jokin : You're right, I should have qualified the "yet." When I put it was recalling that leprosy is found mainly in developing countries and treatment with thalidomide is not controlled as it should. So children have appeared in areas focomielia lepers.

   Shora
   says
10. August 25, 2006 at 2:16 PM
    Miss: Our generation usually do not know what happened, I know because I do medicine, but if you ask any of my brothers or friends know nothing of thalidomide. Pipis: Uis, a page of veganism. With skewed reasoning of why animals should not be used in biomedical research laboratory. The case that concerns us, thalidomide, no comment on anything that was rigged results in animal testing, what things xD As for left-handed and right-handed forms and has answered Marcos. By the way, thanks for the congratulations

    As for the English link you mentioned at the end, when it comes to levosa is specifying with glucose when it is left-handed. It is rare to be called so, normally set as L-glucose (L-glucose).

    
    
11. pipistrellum
    says August 25, 2006 at 3:08 PM and I realized the type of site, but I found it interesting the different effects produce chemicals in humans and animals. That part did not seem wrong.

    certainly know why that glucose is almost always right-handed? I find it curious.

    Noralba
says
12. August 25, 2006 at 5:20 PM Very interesting article, did not know exactly as had been the story. As for the new use of thalidomide believe that now is again legal in Spain and has nothing wrong. All drugs have side effects and are contraindicated in certain circumstances, what is important is to understand the potential impacts and take them properly. As a curiosity many other antiepileptic drugs are teratogenic untilizados in neurology and no one raises her hands to her head because they are marketed. I'd also say that not necessarily Most drugs are bad for Professionals & Researchers, although it is true that in many cases are contraindicated because they do not know the effects on pregnant women not because they know they hurt.

    Shora

    says

    August 25, 2006 at 7:40 PM
Pipistrellum:
13. I think this panel will enlighten my answer about that :

    http://www.phdcomics.com/comics/archive.php?comicid=749 xDD Nah, seriously. The D-glucose is the only biologically active that can be used metabolically because the enzymes recognize. Why did he have to be that and not the other? No idea, some way had to choose to opt for one evolution

    Noralba. With thalidomide had been carried no hands to the head if they are not just right had prescribed to pregnant women and to say nothing of teratogenicity. While the report clearly and controlled drugs, yet have many side effects that may be beneficial, as you say. What happens with thalidomide is leading the "fame" and that behind for the affected families is something that will never change.

    
    
pipistrellum
14. says August 26, 2006 at 9:18 a.m.

    That was the question I had, if the l-glucose in the body functioning well.

    me not clear whether the teratogenic effects are part of life or temporary. If a person ever takes thalidomide children siguietes children you have will be defoma?

    pipistrellum
15. says

    August 26, 2006 at 8:16 PM More than anything, I was saying if left sequels in the gonads or something. Oi For many years a radiologist who had a few children with defects, and could not have more because they ran a high risk of having another child like. But I see no

    lei for a daughter of Adolfo Suarez that chemotherapy given during pregnancy and she was very scared but the doctors what they said not to worry and the baby went well.

    In principle, the placenta protects many things, but not if they used any particular drug that did not pass through the placenta or the other to prevent the pass.

    also heard a case in which a pregnant operated, but they got that anesthesia affects only the mother.

    
    

    Shora

    says
16. August 26, 2006 at 24:49

    are temporary. The drugs are metabolized and excreted in urine over time. There are drugs that endure longer than others, but, to my knowledge, there is none that is permanently in the body (well, removing the high radiation radiopharmaceuticals can be some radiation, but the drugs themselves are removed). Therefore, a decrease from a certain amount, the drug has no appreciable effect. What produces is teratogenic thalidomide itself to intervene in the training of members in the fetus to reach the mother's blood (although not quite know how.) If the drug is gone, the teratogenic effects as well. Apparently teratogenic effects last between 6-7 months.

    valentina says:
17. August 27, 2006 at 11:25 a.m.

    Hello ... at age 22 had lupus, and between medication Furtado received ... THALIDOMIDE dieorn I imagine, was about to get married and my first dream was to become a mother .... soon I got pregnant, and without thalidomide (sold as candies me from a big bottle bllancos transparent) in Cordoba, Argentina professor Dr. Garzon, a dermatologist. Ezekiel was born healthy and I have 4 children, but it is a crime ... .. still used ??????????? The fear I felt at every ultrasound, not like now, it was terrible, her arms look !!!!!! should embrace it denunciarse.un

    Shora
    

    says

    August 27, 2006 at 7:54 PM
    Pipistrellum: Radiation is not the same than drugs. Considerable radiation alters the DNA itself can lead to cell mutations that cause gonadal malformations in offspring genetic. Anyway, this is avoided by using lead shielding, beam steering, etc..
18. Drugs that alter the DNA that I know of are only those used in chemotherapy. Although drugs and disappear over time and have no effect, mutation remains.
    Thalidomide acts by altering the DNA of gonadal cells, if so influence before pregnancy, not during pregnancy. Valentina : Sorry, had to be tough. When will you prescribed thalidomide warned before the possible effects on the child if you get pregnant?

    Ahynara

    says

    September 2, 2006 at 11:21 a.m.
19. guess in Portugal is the prescription of Thalidomide and Spain. Here is only used in cases of multiple myeloma as a last alternative, informed consent must sign a billet of 10 page, which includes a section where he says he should not become pregnant, and for fertile women who are committed to follow a tt º contraception, with a strict medical monitoring.
    pipistrellum

    says

    
    November 26, 2006 at 7:04 a.m.
    
    Kramer has yogurts also have
20. lactic acid enantiomeric versions

    Shora

    says

    November 26, 2006 at 2:42 PM

    Pipistrellum:
    jejeje, lactobacillus, I have an outstanding issue with this organism.
21. karlos

    says

    January 25, 2007 at 4:45 PM
22. I just found your blog engaging and I love ...
    would like to clarify one thing, all drugs, all are poison, depends on the dose that can cure, administration and what they are used. The talimodia for example, help in some cases of cutaneous lupus, and many doctors are hesitant to prescribe it in some cases by bureaucratic obstacles, and the suspicion (normal) of pacientes.Que a woman of 70 years and nun asked every 15 days a pregnancy test, no less peculiar. But if prohibit all drugs at some time have been a possibility of teratogenicity, we are left with the "soda?. The downside is that Shora said that in many developing countries, development is not reported and no control pregnancies, and I know that recently there were few cases in Brazil. A hug

    Shora
23. says

    January 25, 2007 at 8:50 PM karlos: Thalidomide is now used same for ... as you say, cutaneous lupus, recurrent ulcers resistant to conventional therapy Leprosy, a specific type of porphyria, and some types of tumors. With strict medical control nothing happens, the bad thing is when using chaotically. And of course you have is the wake of malformations back, it's hard to forget. And doctors rather than risk, tend to safest.

    I'm glad you like the blog
24. meneame.net
    says October 13, 2007 at 1:50 a.m.

    The disaster of thalidomide ... Interesting article

    physician reveals the effects catastrophic drug thalidomide, used at the end of the 50 early 60's for the treatment of nausea, vomiting, anxiety, insomnia in pregnant women ....

    miracles

    says
    November 1, 2007 at 10:14 PM
25. I limit myself to Argentina and Brazil. then use this damn medication that affected my life.

    I am a victim of the trials. Who takes care of us. Who cares what we feel. We are not mentally retarded people are maimed by scientists. Heal or sick soul?? What is more important?? is known that Most of us have to depend on. will cure diseases for people living freely. Luckily I can be free to think and express myself and now thanks to this device I can, perhaps wondering if I missed something in life? Perhaps the most beautiful to fondle my children? or walk this earth as all, aware of thalidomide kill maim destroy.

    Newsletter Public Health »Blog Archive» Health recognizes that thalidomide was sold in Spain

    says

    November 11, 2007 at 8:48 PM
[...] The Thalidomide catastrophe [...]
26. nilton says

    December 7, 2007 at 10:47 PM

    thalidomide should not ever exist again
    
27.